The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis.Nevertheless, the clinical application of mRNA as a therapeutic tool is limited by its instability and ability to activate i
ESSENTIAL-SUBSTANTIAL, STRUCTURAL AND FUNCTIONAL BASES AND THE DEVELOPMENT PARAMETERS AND FORMATION OF INFORMATION CULTURE OF A PERSON
The article deals with the modern understanding of the information culture of the person in the aspects of its manifestation and formation.The leading functions of information culture as a social, psychological and pedagogical phenomenon are revealed.On the basis of the Foam Bowls analysis of modern scientific approaches the content content of info
Gas-dynamic roof fall during the potash deposits development
In the development of practically all potash salt deposits, the study of gas-dynamic phenomena (GDP) is one of the most difficult tasks to ensure mining safety.Sudden salt and gas outbursts, dynamic breakdown, which are accompanied by intense gas release and possible broken rock carry-over into the mine workings, are associated with GDP.Geological
Development of an in vivo RNAi protocol to investigate gene function in the filarial nematode, Brugia malayi.
Our ability to control diseases caused by parasitic nematodes is constrained by a limited portfolio of effective drugs and a paucity of robust tools to investigate parasitic nematode biology.RNA interference (RNAi) is a reverse-genetics tool with great potential to identify novel drug targets and interrogate parasite gene function, but present RNAi